Do me a favour. Read this passage and interpret it.

This is evidence of the righteous judgment of God, that you may be considered worthy of the kingdom of God, for which you are also suffering—since indeed God considers it just to repay with affliction those who afflict you, and to grant relief to you who are afflicted as well as to us, when the Lord Jesus is revealed from heaven with his mighty angels in flaming fire, inflicting vengeance on those who do not know God and on those who do not obey the gospel of our Lord Jesus.They will suffer the punishment of eternal destruction, away from the presence of the Lord and from the glory of his might,when he comes on that day to be glorified in his saints, and to be marveled at among all who have believed, because our testimony to you was believed.

Most people who read this passage will say that it is talking about the 2nd coming of Jesus. The 2nd coming refers to the end of all time when Jesus returns as he said he would, raising the righteous and wicked; judging all men with the wicked being condemned to hell and the righteous living in glory.

This is not the opinion of the author. The only second coming the Bible expects is that of judgement against Israel in 70 AD.

When reading the Bible, whatever has come before lays the groundwork for what follows. The only context for interpreting this passage is the Olivet Discourse. There is no valid reason to make this text say what it does not.
What follows is a verse from this passage with its predicate in the Olivet Discourse.

A.  This is evidence of the righteous judgment of God, that you may be considered worthy of the kingdom of God, for which you are also suffering
a. Matt. 23:34, 35; Matt 24:9, 29; Matt 25

B. since indeed God considers it just to repay with affliction those who afflict you, and to grant relief to you who are afflicted as well as to us,

b. Matt 24:9, 29; Gen. 12:2,3 with the Immanuel principle

C.  when the Lord Jesus is revealed from heaven with his mighty angels in flaming fire, inflicting vengeance on those who do not know God and on those who do not obey the gospel of our Lord Jesus.    

c. Isa 13:1-5; Gen 12:2,3; Rom. 1; Matt 13:36ff

D. They will suffer the punishment of eternal destruction, [away] from the presence of the Lord and from the glory of his might

d. First thing to be said, the preposition “away” is irresponsibly inserted. It is an interpretation, not translation of the Greek preposition “from.”

e. Matt 3:10-12; 5:22; Matt 7:19; 8:11,12; Matt 13: 36ff, 47ff; Matt 16:27,28; Rev 14:10; 20:9

E. when he comes on that day to be glorified in his saints, and to be marveled at among all who have believed, because our testimony to you was believed.

e. Romans 8; Col. 1:26ff; 1 Thess. 3: 13; Jude .14ff; Rev. 1::7, 18:11